Chronopharmacokinetics: The Circadian Rhythm of Drugs
نویسنده
چکیده
objective: an overview on the most resent study done on chronokinetics, the rhythmic chnges on drug kinetic. Data Source: search in the internet and IOWA drug information service using the term chronokinetic. All papers are reviewed and summarized in this article. Conclusion: the future of kinetic studies of important and dangerous drugs as anticancer agents depend on chronokinetic since we are hopeful to find a specific time of day in which these agents are more effective and less toxic.
منابع مشابه
Chronopharmacokinetics: an Overview
Vital signs and several constituents of the serum and urine show a circadian rhythm. Such a rhythm is also seen in the onset of various diseases. Time dependent changes in the blood volume, functions of liver and kidney etc. have implications for drug availability and circadian changes should be taken in account in pharmacokinetic studies. These changes are the subject of chronopharmacokinetics.
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تاریخ انتشار 2007